UC Santa Cruz Aging and Neurodegeneration Cluster

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Spine neck plasticity controls postsynaptic calcium signals through electrical compartmentalization.

Grunditz, Asa Holbro, Niklaus Tian, Lei Zuo, Yi Oertner, Thomas G

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Dendritic spines have been proposed to function as electrical compartments for the active processing of local synaptic signals. However, estimates of the resistance between the spine head and the parent dendrite suggest that compartmentalization is not tight enough to electrically decouple the synapse. Here we show in acute hippocampal slices that ...

Neutralization of Nogo-A enhances synaptic plasticity in the rodent motor cortex and improves motor learning in vivo.

Zemmar, Ajmal Weinmann, Oliver Kellner, Yves Yu, Xinzhu Vicente, Raul Gullo, Miriam Kasper, Hansjörg Lussi, Karin Ristic, Zorica Luft, Andreas R ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

The membrane protein Nogo-A is known as an inhibitor of axonal outgrowth and regeneration in the CNS. However, its physiological functions in the normal adult CNS remain incompletely understood. Here, we investigated the role of Nogo-A in cortical synaptic plasticity and motor learning in the uninjured adult rodent motor cortex. Nogo-A and its rece...

Fluorescent proteins expressed in mouse transgenic lines mark subsets of glia, neurons, macrophages, and dendritic cells...

Zuo, Yi Lubischer, Jane L Kang, Hyuno Tian, Le Mikesh, Michelle Marks, Alexander Scofield, Virginia L Maika, Shan Newman, Craig Krieg, Paul ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

To enable vital observation of glia at the neuromuscular junction, transgenic mice were generated that express proteins of the green fluorescent protein family under control of transcriptional regulatory sequences of the human S100B gene. Terminal Schwann cells were imaged repetitively in living animals of one of the transgenic lines to show that, ...

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