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Gene repression. H3K27me and PRC2 transmit a memory of repression across generations and during development.

Published in Science (New York, N.Y.)

For proper development, cells must retain patterns of gene expression and repression through cell division. Repression via methylation of histone H3 on Lys27 (H3K27me) by Polycomb repressive complex 2 (PRC2) is conserved, but its transmission is not well understood. Our studies suggest that PRC2 represses the X chromosomes in Caenorhabditis elegans...

Neuroscience. Toward reprogramming gonads to brains.

Published in Science (New York, N.Y.)

A map of the interactome network of the metazoan C. elegans.

Published in Science (New York, N.Y.)

To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) scr...