Vielle, Anne Lang, Jackie Dong, Yan Ercan, Sevinc Kotwaliwale, Chitra Rechtsteiner, Andreas Appert, Alex Chen, Q Brent Dose, Andrea Egelhofer, Thea
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Published in
PLoS genetics
The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites. The DCC localizes to the X chromosomes in hermaphrodites but not in males, and some subunits form a complex homologous to condensin. The mechanis...
Deshong, Alison J Ye, Alice L Lamelza, Piero Bhalla, Needhi
Published in
PLoS genetics
Meiotic chromosome segregation relies on homologous chromosomes being linked by at least one crossover, the obligate crossover. Homolog pairing, synapsis and meiosis specific DNA repair mechanisms are required for crossovers but how they are coordinated to promote the obligate crossover is not well understood. PCH-2 is a highly conserved meiotic AA...
