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H4K20me1 contributes to downregulation of X-linked genes for C. elegans dosage compensation.

Vielle, Anne Lang, Jackie Dong, Yan Ercan, Sevinc Kotwaliwale, Chitra Rechtsteiner, Andreas Appert, Alex Chen, Q Brent Dose, Andrea Egelhofer, Thea ...

Published in PLoS genetics

The Caenorhabditis elegans dosage compensation complex (DCC) equalizes X-chromosome gene dosage between XO males and XX hermaphrodites by two-fold repression of X-linked gene expression in hermaphrodites. The DCC localizes to the X chromosomes in hermaphrodites but not in males, and some subunits form a complex homologous to condensin. The mechanis...

A quality control mechanism coordinates meiotic prophase events to promote crossover assurance.

Deshong, Alison J Ye, Alice L Lamelza, Piero Bhalla, Needhi

Published in PLoS genetics

Meiotic chromosome segregation relies on homologous chromosomes being linked by at least one crossover, the obligate crossover. Homolog pairing, synapsis and meiosis specific DNA repair mechanisms are required for crossovers but how they are coordinated to promote the obligate crossover is not well understood. PCH-2 is a highly conserved meiotic AA...

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