UC Santa Cruz Aging and Neurodegeneration Cluster
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Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injur... PDF available through Get Fulltext Research

Zhang, Ling-Juan Sen, George L Ward, Nicole L Johnston, Andrew Chun, Kimberly Chen, Yifang Adase, Christopher Sanford, James A Gao, Nina Chensee, Melanie ...

Published in Immunity

Type 1 interferons (IFNs) promote inflammation in the skin but the mechanisms responsible for inducing these cytokines are not well understood. We found that IFN-β was abundantly produced by epidermal keratinocytes (KCs) in psoriasis and during wound repair. KC IFN-β production depended on stimulation of mitochondrial antiviral-signaling protein (M...

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