Ennajdaoui, Hanane Howard, Jonathan M Sterne-Weiler, Timothy Jahanbani, Fereshteh Coyne, Doyle J Uren, Philip J Dargyte, Marija Katzman, Sol Draper, Jolene M Wallace, Andrew
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Published in
Cell reports
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) expression correlates with malignancy, but its role(s) in pathogenesis remains enigmatic. We interrogated the IGF2BP3-RNA interaction network in pancreatic ductal adenocarcinoma (PDAC) cells. Using a combination of genome-wide approaches, we have identified 164 direct mRNA targets of IGF...
Ballard, Mimmi S Zhu, Anna Iwai, Naomi Stensrud, Michael Mapps, Aurelia Postiglione, Maira Pia Knoblich, Juergen A Hinck, Lindsay
Published in
Cell reports
Tissue homeostasis requires somatic stem cell maintenance; however, mechanisms regulating this process during organogenesis are not well understood. Here, we identify asymmetrically renewing basal and luminal stem cells in the mammary end bud. We demonstrate that SLIT2/ROBO1 signaling regulates the choice between self-renewing asymmetric cell divis...
