UC Santa Cruz Aging and Neurodegeneration Cluster
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News 422 Publications 11 Members

Predicting sequence and structural specificities of RNA binding regions recognized by splicing factor SRSF1

Wang, Xin Juan, Liran Lv, Junjie Wang, Kejun Sanford, Jeremy R Liu, Yunlong

Published in BMC Genomics

BackgroundRNA-binding proteins (RBPs) play diverse roles in eukaryotic RNA processing. Despite their pervasive functions in coding and noncoding RNA biogenesis and regulation, elucidating the sequence specificities that define protein-RNA interactions remains a major challenge. Recently, CLIP-seq (Cross-linking immunoprecipitation followed by high-...

The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis.

Berman, Andrea J Akiyama, Benjamin M Stone, Michael D Cech, Thomas R

Published in Nature structural & molecular biology

Telomerase is a ribonucleoprotein (RNP) enzyme that maintains the ends of linear eukaryotic chromosomes and whose activation is a hallmark of 90% of all cancers. This RNP minimally contains a reverse transcriptase protein subunit (TERT) that catalyzes telomeric DNA synthesis and an RNA subunit (TER) that has templating, architectural and protein-sc...

Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF.

Semple, Fiona MacPherson, Heather Webb, Sheila Cox, Sarah L Mallin, Lucy J Tyrrell, Christine Grimes, Graeme R Semple, Colin A Nix, Matthew A Millhauser, Glenn L ...

Published in European journal of immunology

β-Defensins are cationic host defense peptides that form an amphipathic structure stabilized by three intramolecular disulfide bonds. They are key players in innate and adaptive immunity and have recently been shown to limit the production of pro-inflammatory cytokines in TLR4-stimulated macrophages. In the present study, we investigate the mechani...

Zinc modulates copper coordination mode in prion protein octa-repeat subdomains

Stellato, Francesco Spevacek, Ann Proux, Olivier Minicozzi, Velia Millhauser, Glenn Morante, Silvia

Published in European Biophysics Journal

In this work we present and analyse XAS measurements carried out on various portions of Prion-protein tetra-octa-repeat peptides in complexes with Cu(II) ions, both in the presence and in the absence of Zn(II). Because of the ability of the XAS technique to provide detailed local structural information, we are able to demonstrate that Zn acts by di...

Spatial constraints dictate glial territories at murine neuromuscular junctions.

Brill, Monika S Lichtman, Jeff W Thompson, Wesley Zuo, Yi Misgeld, Thomas

Published in The Journal of cell biology

Schwann cells (SCs), the glial cells of the peripheral nervous system, cover synaptic terminals, allowing them to monitor and modulate neurotransmission. Disruption of glial coverage leads to axon degeneration and synapse loss. The cellular mechanisms that establish and maintain this coverage remain largely unknown. To address this, we labeled sing...

Tumor Suppressors: Heroes and Villains?

Hinck, Lindsay

Published in Journal of Mammary Gland Biology and Neoplasia

Navigating Breast Cancer: Axon Guidance Molecules as Breast Cancer Tumor Suppressors and Oncogenes

Harburg, Gwyndolen C. Hinck, Lindsay

Published in Journal of Mammary Gland Biology and Neoplasia

Slit, Netrin, Ephrin, and Semaphorin’s roles in development have expanded greatly in the past decade from their original characterization as axon guidance molecules (AGMs) to include roles as regulators of tissue morphogenesis and development in diverse organs. In the mammary gland, AGMs are important for maintaining normal cell proliferation and a...

Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein.

Levitan, Katerina Chereau, David Cohen, Samuel I A Knowles, Tuomas P J Dobson, Christopher M Fink, Anthony L Anderson, John P Goldstein, Jason M Millhauser, Glenn L

Published in Journal of molecular biology

α-Synuclein (α-syn) is the major component of filamentous Lewy bodies found in the brains of patients diagnosed with Parkinson's disease (PD). Recent studies demonstrate that, in addition to the wild-type sequence, α-syn is found in several modified forms, including truncated and phosphorylated species. Although the mechanism by which the neuronal ...

Copper redox cycling in the prion protein depends critically on binding mode.

Liu, Lin Jiang, Dianlu McDonald, Alex Hao, Yuanqiang Millhauser, Glenn L Zhou, Feimeng

Published in Journal of the American Chemical Society

The prion protein (PrP) takes up 4-6 equiv of copper in its extended N-terminal domain, composed of the octarepeat (OR) segment (human sequence residues 60-91) and two mononuclear binding sites (at His96 and His111; also referred to as the non-OR region). The OR segment responds to specific copper concentrations by transitioning from a multi-His mo...

Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 me...

Xiao, Yu Bedet, Cécile Robert, Valérie J P Simonet, Thomas Dunkelbarger, Steve Rakotomalala, Cédric Soete, Gwen Korswagen, Hendrik C Strome, Susan Palladino, Francesca ...

Published in Proceedings of the National Academy of Sciences of the United States of America

Methylation of histone H3 lysine 4 (H3K4me), a mark associated with gene activation, is mediated by SET1 and the related mixed lineage leukemia (MLL) histone methyltransferases (HMTs) across species. Mammals contain seven H3K4 HMTs, Set1A, Set1B, and MLL1-MLL5. The activity of SET1 and MLL proteins relies on protein-protein interactions within larg...

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