UC Santa Cruz Aging and Neurodegeneration Cluster
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News 422 Publications 11 Members

MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elega...

Bender, Lb Suh, J Carroll, Cr Fong, Y Fingerman, Im Briggs, Sd Cao, R Zhang, Y Reinke, V Susan Strome ...

Published in Development

Germ cell development in C. elegans requires that the X chromosomes be globally silenced during mitosis and early meiosis. We previously found that the nuclear proteins MES-2, MES-3, MES-4 and MES-6 regulate the different chromatin states of autosomes versus X chromosomes and are required for germline viability. Strikingly, the SET-domain protein M...

Defining heterochromatin in C. elegans through genome-wide analysis of the heterochromatin protein 1 homolog HPL-2.

Garrigues, Jm Sidoli, S Garcia, Ba Susan Strome

Published in Genome Research

Formation of heterochromatin serves a critical role in organizing the genome and regulating gene expression. In most organisms, heterochromatin flanks centromeres and telomeres. To identify heterochromatic regions in the heavily studied model C. elegans, which possesses holocentric chromosomes with dispersed centromeres, we analyzed the genome-wide...

Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos.

Susan Strome Wood, Wb

Published in Cell

Germ-line granules in C. elegans embryos (P granules) can be visualized by immunofluorescence microscopy using a monoclonal antibody. In mutant zygotes with abnormal spindle orientations and in wild-type zygotes treated with the microtubule inhibitors nocodazole, colcemid, vinblastine, and griseofulvin, both P-granule segregation to the posterior p...

SLIT/ROBO1 signaling suppresses mammary branching morphogenesis by limiting basal cell number.

Macias, H Moran, A Samara, Y Moreno, M Compton, Je Harburg, G Strickland, P Lindsay Hinck

Published in Developmental Cell

In the field of breast biology, there is a growing appreciation for the "gatekeeping function" of basal cells during development and disease processes yet mechanisms regulating the generation of these cells are poorly understood. Here, we report that the proliferation of basal cells is controlled by SLIT/ROBO1 signaling and that production of these...

Characterization and solubilization of pyrrole-imidazole polyamide aggregates.

Hargrove, Ae Jevgenij Raskatov Meier, Jl Montgomery, Dc Dervan, Pb

Published in Journal of Medicinal Chemistry

To optimize the biological activity of pyrrole-imidazole polyamide DNA-binding molecules, we characterized the aggregation propensity of these compounds through dynamic light scattering and fractional solubility analysis. Nearly all studied polyamides were found to form measurable particles 50-500 nm in size under biologically relevant conditions, ...

Estimating the relative populations of 3(10)-helix and alpha-helix in Ala-rich peptides: a hydrogen exchange and high fi...

Glenn Millhauser Stenland, Cj Hanson, P Bolin, Ka Van De Ven, Fj

Published in Journal of Molecular Biology

Recent experimental and theoretical work suggests that alanine-rich peptides fold as a mixture of 3(10)-helix (i —> i + 3 hydrogen bonding) and alpha-helix (i —> i + 4 hydrogen bonding). In order to assess the relative proportions of the two conformers, NMR studies were performed on the 16 residue sequences: Ac-AAAAKAAAAKAAAAKA-NH2 (3K) and Ac-AMAA...

Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis.

Strickland, P Shin, Gc Plump, A Tessier-Lavigne, M Lindsay Hinck

Published in Development

Development of many organs, including the mammary gland, involves ductal morphogenesis. Mammary ducts are bi-layered tubular structures comprising an outer layer of cap/myoepithelial cells (MECs) and an inner layer of luminal epithelial cells (LECs). Slit2 is expressed by cells in both layers, with secreted SLIT2 broadly distributed throughout the ...

Pairing centers recruit a Polo-like kinase to orchestrate meiotic chromosome dynamics in C. elegans.

Harper, Nc Rillo, R Jover-Gil, S Assaf, Zj Needhi Bhalla Dernburg, Af

Published in Developmental Cell

Faithful segregation of homologous chromosomes during meiosis requires pairing, synapsis, and crossing-over. In C. elegans, homolog pairing and synapsis depend on pairing centers (PCs), special regions near one end of each chromosome that interact with the nuclear envelope (NE) and cytoplasmic microtubules. Here, we report that PCs are required for...

Control of a kinesin-cargo linkage mechanism by JNK pathway kinases.

Horiuchi, D Collins, Ca Bhat, P Barkus, Rv Diantonio, A Saxton, Wm

Published in Current Biology

Long-distance organelle transport toward axon terminals, critical for neuron development and function, is driven along microtubules by kinesins [1, 2]. The biophysics of force production by various kinesins is known in detail. However, the mechanisms of in vivo transport processes are poorly understood because little is known about how motor-cargo ...

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