Early embryogenesis in Caenorhabditis elegans: the cytoskeleton and spatial organization of the zygote.

Published in BioEssays

Netrin-1-independent adenosine A2b receptor activation regulates the response of axons to netrin-1 by controlling cell s...

Published in Journal of Neurochemistry

Growth cone response to the bifunctional guidance cue netrin-1 is regulated by the activity of intracellular signaling intermediates such as protein kinase C-alpha (PKCalpha) and adenylyl cyclase. Among the diverse cellular events these enzymes regulate is receptor trafficking. Netrin-1, itself, may govern the activity of these signaling intermedia...

Brain accumulation and toxicity of Mn(II) and Mn(III) exposures.

Published in Toxicological Sciences

Concern over the neurotoxic effects of chronic moderate exposures to manganese has arisen due to increased awareness of occupational exposures and to the use of methylcyclopentadienyl manganese tricarbonyl, a manganese-containing gasoline antiknock additive. Little data exist on how the oxidation state of manganese exposure affects toxicity. The ob...

PrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease?

Published in Prion

Knockout of the cellular prion protein (PrP(C)) in mice is tolerated, as is complete elimination of the protein s N-terminal domain. However, deletion of select short segments between the N- and C-terminal domains is lethal. How can one reconcile this apparent paradox? Research over the last few years demonstrates that PrP(C) undergoes α-cleavage i...

Susceptibility to Paget s disease of bone is influenced by a common polymorphic variant of osteoprotegerin.

Published in Journal of Bone and Mineral Research

ATP mediates rapid microglial response to local brain injury in vivo

Published in Nature Neuroscience

Views of helical peptides: a proposal for the position of 3(10)-helix along the thermodynamic folding pathway.

Published in Biochemistry

A "slow" homotetrameric kinesin-related motor protein purified from Drosophila embryos.

Published in Journal of Biological Chemistry

Pan-kinesin peptide antibodies (Cole, D. G., Cande, W. Z., Baskin, R. J., Skoufias, D. A., Hogan, C. J., and Scholey, J. M. (1992) J. Cell Sci. 101, 291-301; Sawin, K. E., Mitchinson, T. J., and Wordeman, L. G. (1992) J. Cell Sci. 101, 303-313) were used to identify and isolate kinesin-related proteins (KRPs) from Drosophila melanogaster embryonic ...

Succimer and the reduction of tissue lead in juvenile monkeys.

Published in Toxicology and Applied Pharmacology

The extent to which succimer (2,3-dimercaptosuccinic acid, DMSA) chelation reduces target organ lead (Pb) levels, including the skeleton, relative to the cessation of Pb exposure is a primary consideration in evaluating its efficacy for reducing toxicity in children. Here, we utilized a rhesus monkey model of childhood Pb exposure and a sensitive s...

Electron spin labels.

Published in G Protein Coupled Receptors - Structure