UC Santa Cruz Aging and Neurodegeneration Cluster
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News 422 Publications 11 Members

Metal contamination of home garden soils and cultivated vegetables in the province of Brescia, Italy: implications for h...

Ferri, Roberta Hashim, Dana Smith, Donald R Guazzetti, Stefano Donna, Filippo Ferretti, Enrica Curatolo, Michele Moneta, Caterina Beone, Gian Maria Lucchini, Roberto G ...

Published in The Science of the total environment

Prolonged industrial emissions increase median metal concentrations and most soluble fractions (BCR F1+F2) in home garden soils near ferroalloy plants. Areas near ferroalloy plant sites had spinach Cd and Pb metal concentrations several-fold above maximum standard references. We recommend thorough washing of vegetables to minimize metal exposure.

Impact of ferromanganese alloy plants on household dust manganese levels: implications for childhood exposure.

Lucas, E L Bertrand, P Guazzetti, S Donna, F Peli, M Jursa, T P Lucchini, R Smith, D R

Published in Environmental research

Adolescents living in communities with ferromanganese alloy plant activity have been shown to exhibit deficits in olfactory and fine motor function. Household dust may serve as an important manganese (Mn) exposure pathway to children, though dust Mn concentrations have not previously been measured to assess household contamination from ferromangane...

Oral methylphenidate alleviates the fine motor dysfunction caused by chronic postnatal manganese exposure in adult rats....

Beaudin, Stéphane A Strupp, Barbara J Lasley, Stephen M Fornal, Casimir A Mandal, Shyamali Smith, Donald R

Published in Toxicological sciences : an official journal of the Society of Toxicology

Developmental manganese (Mn) exposure is associated with motor dysfunction in children and animal models, but little is known about the underlying neurochemical mechanisms or the potential for amelioration by pharmacotherapy. We investigated whether methylphenidate (MPH) alleviates fine motor dysfunction due to chronic postnatal Mn exposure, and wh...

The DREAM complex promotes gene body H2A.Z for target repression.

Latorre, Isabel Chesney, Michael A Garrigues, Jacob M Stempor, Przemyslaw Appert, Alex Francesconi, Mirko Strome, Susan Ahringer, Julie

Published in Genes & development

The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, D...

Manganese concentrations in soil and settled dust in an area with historic ferroalloy production

Pavilonis, Brian T Lioy, Paul J Guazzetti, Stefano Bostick, Benjamin C Donna, Filippo Peli, Marco Zimmerman, Neil J Bertrand, Patrick Lucas, Erika Smith, Donald R ...

Published in Journal of Exposure Science & Environmental Epidemiology

Ferroalloy production can release a number of metals into the environment, of which manganese (Mn) is of major concern. Other elements include lead, iron, zinc, copper, chromium, and cadmium. Mn exposure derived from settled dust and suspended aerosols can cause a variety of adverse neurological effects to chronically exposed individuals. To better...

Maternal blood and hair manganese concentrations, fetal growth, and length of gestation in the ISA cohort in Costa Rica....

Mora, Ana M van Wendel de Joode, Berna Mergler, Donna Córdoba, Leonel Cano, Camilo Quesada, Rosario Smith, Donald R Menezes-Filho, José A Eskenazi, Brenda

Published in Environmental research

Mn plays an important role in fetal development, but the extent to which environmental exposures may cause adverse health effects to the developing fetus is not well understood. Among women living near banana plantations in Costa Rica, we did not observe linear or nonlinear associations of Mn concentrations with lowered birth weight or head circumf...

The RNAissance family: SR proteins as multifaceted regulators of gene expression.

Howard, Jonathan M Sanford, Jeremy R

Published in Wiley interdisciplinary reviews. RNA

Serine and arginine-rich (SR) proteins play multiple roles in the eukaryotic gene expression pathway. Initially described as constitutive and alternative splicing factors, now it is clear that SR proteins are key determinants of exon identity and function as molecular adaptors, linking the pre-messenger RNA (pre-mRNA) to the splicing machinery. In ...

Genetic Incorporation of the Unnatural Amino Acid p-Acetyl Phenylalanine into Proteins for Site-Directed Spin Labeling.

Evans, Eric G B Millhauser, Glenn L

Published in Methods in enzymology

Site-directed spin labeling (SDSL) is a powerful tool for the characterization of protein structure and dynamics; however, its application in many systems is hampered by the reliance on unique and benign cysteine substitutions for the site-specific attachment of the spin label. An elegant solution to this problem involves the use of genetically enc...

Copper–zinc cross-modulation in prion protein binding

Stellato, Francesco Minicozzi, Velia Millhauser, Glenn L. Pascucci, Marco Proux, Olivier Rossi, Giancarlo C. Spevacek, Ann Morante, Silvia

Published in European Biophysics Journal

In this paper we report a systematic XAS study of a set of samples in which Cu(II) was progressively added to complexes in which Zn(II) was bound to the tetra-octarepeat portion of the prion protein. This work extends previous EPR and XAS analysis in which, in contrast, the effect of adding Zn(II) to Cu(II)–tetra-octarepeat complexes was investigat...

Determinants of manganese levels in house dust samples from the CHAMACOS cohort.

Gunier, R B Jerrett, M Smith, D R Jursa, T Yousefi, P Camacho, J Hubbard, A Eskenazi, B Bradman, A

Published in The Science of the total environment

Manganese (Mn) is an essential nutrient, but at high exposure levels Mn is a neurotoxicant. The fungicides maneb and mancozeb are approximately 21% Mn by weight and more than 150,000 kg are applied each year to crops in the Salinas Valley, California. It is not clear, however, whether agricultural use of these fungicides increases Mn levels in home...

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